Restricting the heat can slow down the biological “clock” operation

Beijing Science and Technology Daily September 18 (Reporter Zhang Meng then) British “Nature Communications” magazine published an article on the 17th mouse and primate research papers suggested that caloric restriction can slow down “epigenetic clock.” Previously, scientists have studied worms, mice, and primates to conclude that heat limits can prolong life and that the new study associates life with the “epigenetic clock” and shows that the “clock” is a study Important biomarker of aging. If we say that our genome is a list of all the genes in the body, then the epigenetic marker (such as methylation) is a string of instructions related to DNA (DNA) for how to “correctly read” the gene. Previous studies have shown that DNA methylation in cells varies over time and can be used as a biomarker of each cell age, like an “epigenetic clock”. Known cancer and neurodegenerative diseases, are associated with an increase in the apparent genetic age of diseased tissue. In order to study the relationship between epigenetic clocks and longevity, a group of research teams in the United States, Temple University, compared the DNA methylation patterns in mice of different ages, primates and humans, Concept of the genetic clock “running the same speed and life. In mammals (such as mice) with shorter life expectancy, the apparent genetic markers of cells change faster than mammals (such as humans) with longer lifetimes. Then, the team measured the rate of apparent genetic senescence in mice and primates that had been strictly controlled by dietary calories and found that the calorie-restricted animal’s apparent genetic senescence rate was slower than that of the control group. This study shows that epigenetic senescence rates or determine the life span of mammals. In addition, it also provides evidence to support the “epigenetic clock” as an important marker of biological senescence.

Article By :

Leave a Reply

Your email address will not be published. Required fields are marked *