Porcine islet transplantation for type 1 diabetes is expected to enter clinical application

presided over the cultivation of medical donor pig Chinese scientist Wang Wei interview. September 8, presided over the cultivation of medical donor pig Chinese scientists, Central South University, Xiangya three hospital professor Wang Wei led the scientific research team announced that the Chinese Academy of Sciences, The “newborn pig” islet transplantation for the treatment of small samples of type 1 diabetes clinical study “through the end of the expert review, it is recommended to incorporate three types of medical technology management and the development of appropriate clinical application of technical specifications, the technology has to meet the conditions for clinical application. “This marks the world’s top technology from the ivory tower to tens of millions of ordinary patients.” Wang said that from now on, their research team with the Chinese domestic hospital, has the ability to treat diabetic patients. The team plans to work through two years, and strive to achieve more than 10,000 people each year out of the bitter diabetes purposes. Pigs are currently found to be the most suitable for xenografts to provide organ species, and its organ functional structure is almost identical to the human body. Transplantation of porcine islets is extracted from pigs that meet the United Nations World Health Organization criteria for non-designated pathogens (DPF). In 2012, the three hospitals of Central South University successfully cultivated medical grade animal donor “newborn pig”, and built the world’s second, Asia’s first biosafety donor pig breeding center. “Regeneration of the ‘newborn pig’ from the patient’s own regulatory T cells, it can make the patient’s rejection of transplanted islets significantly reduced.” According to Wang Wei, T cells are the body “Sentinel” cells, found that foreign Cells will be issued an alarm to mobilize the body’s rejection system to attack foreign cells. Through training to understand that transplanted cells are “friends” non-“enemy”, can greatly reduce the use of anti-rejection drugs to improve the transplant effect. July 2013 so far, Wang Wei team has 10 patients with type 1 diabetes “newborn pig” pig islet transplantation study. These patients were significantly improved condition, blood sugar stable normal, glycosylated hemoglobin also returned to normal, the overall use of insulin to reduce more than 60%. According to the international consensus of islets called planted comprehensive score, an average of 0.62 points, the best to reach 0.88 points (completely cure diabetes 1 point), far higher than Japan’s highest 0.17 points effect. In this review, the expert group agreed that Wang Wei team project in the international community for the first time to establish a transplant donor culture – Porcine Islet extraction – clinical application of a complete technical system, with a reliable biosafety, made the current international xenotransplant The best effect, can be applied to the treatment of type 1 diabetes, reaching the international leading level. “We have established the international leading large-scale efficient pig islet separation and purification system and detection system, like the same as the production line to extract large quantities of pig islets, but also to ensure the purity and activity of the extraction of islets.” Wang said that this new technology For the large-scale transplanting pig islets opened up a broad road. (Finish)

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