Live cells “internal clock” for the first time found

According to the physicist organization network reported on the 11th, the US scientists use advanced fluorescence microscopy technology, the first time the human living cells within the nucleus of the shape of the dynamic changes in the study found that the United States, the United States, the United States, The nucleus shows rapid volatility. This “internal clock signal” indicates that humans first find the physical properties that characterize cell cycle changes and provide a new way to understand the composition of life and the causes of disease. Previous studies have only been carried out after the cells developed at a point in the life cycle, and the extracted cells are already in the “dead” state of cessation. By this type of research, scientists have known that in a cell life cycle The shape and size of the nucleus in the nucleus will change dramatically. But in view of technical constraints, can not live cells within the nuclear changes to track, so the shape of the nucleus in the cell life cycle of the various periods of time has changed, has been unknown. Published in the Journal of the American Academy of Sciences, said the latest study, New York University Department of Physics Associate Professor Alexandra Zidovska and colleagues using fluorescence microscopy technology to observe the living cell nuclei shape at various points in time fast Subtle changes. They found a type of activity that was not previously detected in the human nucleus: under fluorescence microscopy, the nucleus membrane flickers every few seconds, meaning that its size fluctuates every few seconds, and more importantly, The magnitude of this shape fluctuates in the entire cell cycle. Zidovanska explained that the nuclear membrane is the outermost structure of the nucleus, both to protect the DNA molecules within the nuclear from damage, but also the material exchange channel. Nuclear membrane in the structure and function of the wrong words, will lead to cardiomyopathy, muscular dystrophy and cancer and other developmental genetic disease. “The nuclear envelope fluctuation process can be seen as the internal clock of the cell, and the fluctuating signal can tell people where the cells are in the life cycle, and the mechanism behind them is important for understanding the important components of healthy cells and the etiology of diseased cells,” he said.

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